Nano Particles – Culprit hidden in plain sight in Alzheimer disease development

Cultocracy note :

In this new study conducted in Mexico City high concentrations of transition metal nano particles were found in the neuronal cells of the human brain . Transition metals exhibit high electrical conductivity & are paramagnetic . Paramagnetic nano particles are used extensively as a contrast agent in functional magnetic resonance imaging . Metal nano particles are now known to play a major role in neuro-degenerative diseases such as alzheimers .

Dementia Tax anybody ?



Summary

A new study heightens concerns over the detrimental short- and long-term impact of airborne iron-rich strongly magnetic combustion-derived nanoparticles present in young urbanites’ brains.

A new study by researchers at the University of Montana, Universidad del Valle de México, Instituto Nacional de Pediatría, Boise State, and Universidad Nacional Autónoma de México, heightens concerns over the detrimental short- and long-term impact of airborne iron-rich strongly magnetic combustion-derived nanoparticles (CDNPs) present in young urbanites’ brains. Using transmission electron microscopy, the researchers documented by abundant combustion nanoparticles in neurons, glial cells, choroid plexus, and neurovascular units of Mexico City children, teens and young adults chronically exposed to concentrations above the US-EPA standards for fine particulate matter. Residents in Mexico City are exposed from conception to harmful neurotoxic air pollutants. These findings are published in the Journal of Alzheimer’s Disease.

The detrimental impact of these tiny particles getting into the brain through the nasal and olfactory epithelium, the lungs and the gastrointestinal system is quickly recognized by extensive alterations in critical neuronal organelles including mitochondria, as well as axons and dendrites. Since these nanoparticles are in close contact with neurofilaments, glial fibers and chromatin, the researchers are very concerned about their potential for altering microtubule dynamics, accumulation and aggregation of unfolded proteins, mitochondrial dysfunction, altered calcium homeostasis and insulin signaling, and epigenetic changes.

Mexico City children, teens and young adults have shown key markers of Alzheimer’s disease (AD): hyperphosphorylated tau and amyloid plaques along with significant brain and intrathecal neuroinflammation, dysregulated immune responses, breakdown of epithelial and endothelial barriers, extensive damage to the neurovascular unit, and brain accumulation of metals associated with combustion. Moreover, these seemingly healthy young people have olfaction deficits, dysregulation of feeding hormones, deficiencies in attention and short-term memory, and below-average scores in Verbal and Full Scale IQ compared to age, gender, and socioeconomic status-matched low air pollution residents. The cognitive problem is particularly serious for overweight female teens carrying an allele of the apolipoprotein E (APOE) ?4, the most prevalent genetic risk factor for AD.

“In the context of serious continuous exposures to high concentrations of fine particulate matter (PM 2.5) and ozone, our current electron microscopy findings and the extensive literature associating air pollutants with brain damage, the issue of who is at risk of neurodegeneration at an early age should be an urgent public health concern,” said Dr. Lilian Calderon-Garcidue?as. “The effects of poverty, urban violence and urban stress on impaired cognitive skills are also very important for the developing brain and can’t be ignored. We know gender, BMI, and APOE influence children’s cognitive responses to air pollution.”

According to the researchers, the problem of having combustion-derived nanoparticles in children’s brains — developing brains — is very serious. These particles are ubiquitous and present in high concentrations in children as young as 3 years old. The particles contain transition neurotoxic metals and they are certainly causing extensive brain damage in key organelles. “The predominant combustion particles in young brains have properties that enable them to cause oxidative damage because these nanoparticles are capable of crossing all barriers. No barrier is spared,” Dr. Calderón-Garcidue?as emphasized.

Angélica González-Maciel added, “People with children and teens struggling in school and facing a significant increase of violence in school, streets, parks, and public transportation are deeply concerned about the impact these particles have on children’s behavioral patterns and academic performance and parents question what they can do to protect their families.”

Read the full article here at Science Daily

Purchase the full article here at IOS Press


Related :

  1. Toxic air pollution nanoparticles discovered in the human brain
  2. Chemtrails – The Global Matrix
  3. Europe Pesticide Ban , Bees & Magnetite Nano Particles
  4. Metal Oxide Nano-Particles , Autism & Gulf War Syndrome
  5. Cannabis compounds could be used to treat Alzheimer’s
  6. Magnetite pollution nanoparticles in the human brain (PDF)
  7. Nano Straws & Scarecrows
  8. Nano Implants – Neural Smartdust
  9. Mapping the mind with nanotechnology
  10. Towards Wireless Brain Computer Interface: Light Activation of Neurons Via Nanoparticles

Also related :

  1. More amyloid in the brain, more cognitive decline
  2. A Look Into the Dramatic Rise in Alzheimer’s Cases
  3. Amyloidb and Transition Metals: Structure and Reactivity
  4. Can metal-exposure induce innate immune reactivity in brain cells and thus contribute to neurotoxicity?

Further related :

  1. Functional MRI
  2. Functional magnetic resonance imaging
  3. Magnetic Nanoparticles In The Brain and MRI
  4. Using Nanoparticle Imaging Probes (PDF)
  5. Paramagnetic nanoparticles as potential MRI contrast agents
  6. Viral nanoparticles donning a paramagnetic coat
  7. Nanoparticles to aid brain imaging
  8. BOLD Contrast Mechanism
  9. Brain–computer interface
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